Autologous Cell Transplants

Autologous Cell Transplants: Procedure, Side Effects & More

When your bone marrow is damaged, an autologous stem cell transplant replaces it with healthy blood stem cells from your own body. The patient’s stem cells are used in autologous stem cell transplantation to carry out the surgery. 

High-dose, rigorous chemotherapy or radiation therapy treatments are occasionally used to treat cancer. This form of treatment has the potential to harm your stem cells as well as your immune system. 

The stem cells are subsequently administered back to the patient’s body after large doses of chemotherapy, either in combination with or without radiation therapy. Blood cancer patients frequently undergo this type of transplant.

The purpose of an autologous stem cell transplantation is to re-establish the body’s capacity to produce healthy blood cells following high-dose chemotherapy or radiation.

The procedure of autologous stem cell transplantation

During autologous stem cell transplantation, doctors extract stem cells from the bloodstream.

The bone marrow stem cells are transported into the peripheral bloodstream through a mobilisation process, where the collection procedure starts. The stem cells are harvested from the blood through a method known as apheresis. This procedure is repeated several times to gather the necessary number of stem cells. 

After harvesting, the stem cells are frozen and stored in the Stem Cell Processing and Cryopreservation Laboratory. To eradicate any leftover cancer cells, the doctor may use radiation therapy or heavy doses of chemotherapy. 

The transplant usually happens two days after the end of these treatments. The frozen stem cells are thawed and administered back into your body via an intravenous infusion after high-dose chemotherapy.

Engraftment is the process of producing new blood cells. The stem cells move to the bone marrow after reaching the bloodstream and start the engraftment process. Usually, the treatment lasts an hour.

Autologous stem cell transplantation is a procedure in which stem cells are harvested from the patient’s own body and then transplanted back into the patient. This type of stem cell transplantation is often used to treat leukemia and lymphoma, as well as other blood disorders. The first step in the procedure is to collect the stem cells from the patient’s bone marrow or peripheral blood. The stem cells are then purified and frozen until they are needed for transplantation. When the stem cells are ready to be transplanted, they are thawed and injected into the patient’s bloodstream. The stem cells then travel to the bone marrow, where they begin to produce new blood cells. This process can take several weeks, but it eventually leads to a full recovery from the disease.

Side effects of autologous stem cell transplantation

A transplant using one’s cells is a complex procedure. The side effects will vary depending on the high-dose therapy you receive. A week after autologous stem cell transplantation, the body starts to experience the effects of chemotherapy or radiation.

One of the most serious side effects of stem cell transplantation is graft-versus-host disease (GVHD). This occurs when the transplanted stem cells view the patient’s body as foreign and mount an immune response. GVHD can cause a wide range of symptoms, including rash, diarrhea, and liver damage. In some cases, it can be fatal. Other side effects of stem cell transplantation include infections, bleeding, and fatigue. These side effects are usually temporary and resolve with time. However, stem cell transplantation is a very intense treatment and patients should be prepared for the possibility of serious side effects.

Autologous stem cell transplantation is a type of stem cell therapy that uses stem cells from the patient’s own body. The stem cells are removed from the patient’s blood or bone marrow and then injected back into the patient. This treatment is used to treat certain types of cancer, such as leukemia and lymphoma. It can also be used to treat other conditions, such as multiple sclerosis and autoimmune diseases.

Loss of Appetite: 

Chemotherapy, traumatic brain injury, and other drugs can temporarily alter your senses of taste and, occasionally, smell. 

Many patients report that food tastes suddenly like cardboard or paper.

Chemotherapy, traumatic brain injury, and occasionally antibiotics can all cause nausea or vomiting.

Mouth and Throat Aches: 

The chemotherapy medications used in this therapy can result in mouth and throat aches. Also possible are painful mouth ulcers.

Diarrhoea 

Diarrhoea can be caused by chemotherapy, TBI, and some antibiotics. It may result in skin deterioration and infection near the rectum.

Hair Loss: 

Chemotherapy frequently has this side effect. Generally, you lose every hair on your head. You can have thinning or hair loss in your eyebrows, eyelashes, and other body hair.

change in vision

After taking certain medications for a while, you could feel sleepy or find it difficult to concentrate on your eyes.

Infections

You can easily contract dangerous infections for at least the first six weeks following transplant until the new stem cells produce white blood cells (engraftment). During this first stage of neutropenia, bacterial infections are the most frequent. 

The danger of infection lowered after engraftment, but it is still possible. The immune system may not function as it should for six to twelve months following the transplant.

Cost and success rate of autologous stem cell transplant

The bone marrow transplant cost in India is cheaper compared to other countries even the cancer treatment in India  is cheaper. The average cost of a bone marrow transplant in India is between 12 to 15 lakh rupees for an allogeneic transplant and 14 to 20 lakh rupees for an autologous transplant.

The success rate of autologous stem cell transplantation varies depending on your diagnosis and the severity of your ailment, among other things.

With cutting-edge technology and the best doctors, India offers an economical bone marrow transplant cost with a high success rate.

“In recent years, the success rate of bone marrow transplants has increased to 90%”.

People from Nigeria can travel to India for an affordable and successful treatment because the cost of stem cell therapy here is significantly lower than what it would be anywhere in the western world.

stem cell transplantation is a promising treatment for a variety of diseases, but it is not without its risks. The procedure is costly and the success rate is not 100%, so patients and their families must weigh the pros and cons carefully before proceeding. stem cell transplantation involves taking stem cells from the patient’s own body and injecting them into the bloodstream. The stem cells then travel to the bone marrow, where they begin producing new blood cells. This can help to improve the patient’s overall health and well-being, but there are no guarantees. stem cell transplantation is a complex and expensive procedure, and it is not always successful. Nevertheless, it offers hope to patients with few other options.

Summary

Autologous stem cell transplantation is the process of using a person’s healthy stem for transplantation. The procedure is frequently used to treat patients with blood malignancy.

Now that you know the autologous stem cell transplantation process, you can choose HBG medical aid for successful therapy. The HBG offers medical support to people travelling to India for medical treatment from all around the world.

After receiving therapy, you may experience side effects like nausea, hair loss, infections, sore throats, pains, and appetite loss, among others. Everything related to the procedure, side effects, and treatment cost is covered above. 

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